Update 12:25 p.m.
Route 422 was reopened just before 12:15 p.m.
Update 11:35 a.m.:
Route 422 eastbound will be closed for at least another hour, according to radio reports. Traffic is stopped and very backed up.
Traffic on side roads is also heavy due to the closure.
Scanner reports indicate a two-vehicle crash involving a car and a PennDOT truck has the eastbound lane of Route 422 closed from the Royersford/Trappe exit to the Collegeville exit.
The accident happened around 10 a.m. Reports are that two people were trapped in the car; both were extricated by 10:45 a.m. and being transported to Paoli Hospital.
Patch will have updates on the story as it develops.